Review
Nature Reviews Molecular Cell Biology 7, 437-447 (June 2006) | doi:10.1038/nrm1945
Chromatin remodelling: the industrial revolution of DNA around histones
Anjanabha Saha1, Jacqueline Wittmeyer1 & Bradley R. Cairns1 About the authors
Abstract
Chromatin remodellers are specialized multi-protein machines that enable access to nucleosomal DNA by altering the structure, composition and positioning of nucleosomes. All remodellers have a catalytic ATPase subunit that is similar to known DNA-translocating motor proteins, suggesting DNA translocation as a unifying aspect of their mechanism. Here, we explore the diversity and specialization of chromatin remodellers, discuss how nucleosome modifications regulate remodeller activity and consider a model for the exposure of nucleosomal DNA that involves the use of directional DNA translocation to pump 'DNA waves' around the nucleosome.
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Author affiliations
- Department of Oncological Sciences and Howard Hughes Medical Institute, Huntsman Cancer Institute, University of Utah School of Medicine, 2000 Circle of Hope, Salt Lake City, Utah 84112, USA.
Correspondence to: Bradley R. Cairns1 Email: brad.cairns@hci.utah.edu
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