Review
Nature Reviews Molecular Cell Biology 7, 359-371 (May 2006) | doi:10.1038/nrm1911
VEGF receptor signalling ? in control of vascular function
Anna-Karin Olsson1, Anna Dimberg1, Johan Kreuger1 & Lena Claesson-Welsh1 About the authors
Abstract
Vascular endothelial growth-factor receptors (VEGFRs) regulate the cardiovascular system. VEGFR1 is required for the recruitment of haematopoietic precursors and migration of monocytes and macrophages, whereas VEGFR2 and VEGFR3 are essential for the functions of vascular endothelial and lymphendothelial cells, respectively. Recent insights have shed light onto VEGFR signal transduction and the interplay between different VEGFRs and VEGF co-receptors in development, adult physiology and disease.
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Author affiliations
- Department of Genetics and Pathology, Rudbeck Laboratory, Dag Hammarskjöldv. 20, 751 85 Uppsala, Sweden
Correspondence to: Lena Claesson-Welsh1 Email: Lena.Welsh@genpat.uu.se
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