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Nature Reviews Molecular Cell Biology 7, 225–230 (1 March 2006) | doi:10.1038/nrm1861

A visual approach to proteomics

Stephan Nickell , Christine Kofler , Andrew P. Leis & Wolfgang Baumeister

Cryo-electron tomography is an emerging imaging technique that will allow us to map molecular landscapes inside cells. This 'visual proteomics' will complement and extend mass-spectrometry-based inventories, and will provide a quantitative description of the macromolecular interactions that underlie cellular functions.