Access

Review

Nature Reviews Molecular Cell Biology 7, 188–197 (1 March 2006) | doi:10.1038/nrm1859

Structural systems biology: modelling protein interactions

Patrick Aloy & Robert B. Russell

The difficulties that are associated with the experimental determination of atomic structures for interacting proteins mean that predictive methods are needed for progress. Such structural details can be used to turn abstract system representations into models that more accurately reflect biological reality.