Review

Nature Reviews Molecular Cell Biology 7, 85-96 (February 2006) | doi:10.1038/nrm1837

Critical nodes in signalling pathways: insights into insulin action

Cullen M. Taniguchi1,2, Brice Emanuelli1,2 & C. Ronald Kahn1,2  About the authors

Top

Physiologically important cell-signalling networks are complex, and contain several points of regulation, signal divergence and crosstalk with other signalling cascades. Here, we use the concept of 'critical nodes' to define the important junctions in these pathways and illustrate their unique role using insulin signalling as a model system.

Author affiliations

  1. Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA.
  2. These authors contributed equally to this work.

Correspondence to: C. Ronald Kahn1,2 Email: c.ronald.kahn@joslin.harvard.edu

MORE ARTICLES LIKE THIS

These links to content published by NPG are automatically generated.

NEWS AND VIEWS

Diabetes Kicking off the insulin cascade

Nature News and Views (14 Dec 2006)

Drugging the PI3 kinome

Nature Biotechnology News and Views (01 Jul 2006)

See all 3 matches for News And Views

Extra navigation

Subscribe

Subscribe to Nature Reviews Molecular Cell Biology

Search PubMed for

Open Innovation Challenges

  • Corrosion Inhibitor

    • Deadline: Aug 19 2009
    • Reward: $10,000 USD

    The Seeker is looking for inhibitors of corrosion. This Challenge requires only a written descripti...

  • Mitigating Zinc Corrosion

    • Deadline: Aug 23 2009
    • Reward: $20,000 USD

    The Seeker is looking for novel methods to mitigate zinc corrosion/gassing in alkaline media. This ...

natureproducts


Advertisement