Review

Nature Reviews Molecular Cell Biology 7, 85-96 (February 2006) | doi:10.1038/nrm1837

Critical nodes in signalling pathways: insights into insulin action

Cullen M. Taniguchi1,2, Brice Emanuelli1,2 & C. Ronald Kahn1,2  About the authors

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Physiologically important cell-signalling networks are complex, and contain several points of regulation, signal divergence and crosstalk with other signalling cascades. Here, we use the concept of 'critical nodes' to define the important junctions in these pathways and illustrate their unique role using insulin signalling as a model system.

Author affiliations

  1. Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA.
  2. These authors contributed equally to this work.

Correspondence to: C. Ronald Kahn1,2 Email: c.ronald.kahn@joslin.harvard.edu

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