Review
Nature Reviews Molecular Cell Biology 7, 85-96 (February 2006) | doi:10.1038/nrm1837
Critical nodes in signalling pathways: insights into insulin action
Cullen M. Taniguchi1,2, Brice Emanuelli1,2 & C. Ronald Kahn1,2 About the authors
Abstract
Physiologically important cell-signalling networks are complex, and contain several points of regulation, signal divergence and crosstalk with other signalling cascades. Here, we use the concept of 'critical nodes' to define the important junctions in these pathways and illustrate their unique role using insulin signalling as a model system.
- View At a Glance
Author affiliations
- Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA.
- These authors contributed equally to this work.
Correspondence to: C. Ronald Kahn1,2 Email: c.ronald.kahn@joslin.harvard.edu
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Grb-ing hold of insulin signalingNature Structural & Molecular Biology News and Views (01 Aug 2009)
Diabetes Kicking off the insulin cascadeNature News and Views (14 Dec 2006)
See all 5 matches for News And ViewsRESEARCH
Systems-level interactions between insulin?EGF networks amplify mitogenic signalingMolecular Systems Biology Article (07 Apr 2009)
Over-expression of NYGGF4 inhibits glucose transport in 3T3-L1 adipocytes via attenuated phosphorylation of IRS-1 and AktActa Pharmacologica Sinica Original Article
See all 31 matches for Research
