Abstract

Technologies for genome-wide analyses typically undergo a transition from a discovery phase to a scoring phase. In the discovery phase, the genomic universe is explored and all pertinent data are noted. In the scoring phase, relevant entities are screened to reveal groups of genes that are associated with specific biological processes or conditions. In this article, we propose that the transition from a discovery to a scoring phase is also essential, feasible and imminent for proteomics.

Author affiliations

1. Bernhard Kuster and Markus Schirle are at the Department of Analytical Sciences and Informatics, Cellzome AG, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
2. Parag Mallick is at the Louis Warschaw Prostate Cancer Center, Cedars-Sinai Medical Center, 8631 West Third Street, Suite 1001E, Los Angeles, California 90048, USA.
3. Ruedi Aebersold is at the Institute for Molecular Systems Biology, ETH Hönggerberg HPT E 78, Wolfgang Pauli-Strasse 16, CH-8093 Zürich, Switzerland.

Correspondence to: Bernhard Kuster¹ Email: bernhard.kuster@cellzome.com

Correspondence to: Ruedi Aebersold³ Email: aebersold@imsb.biol.ethz.ch

Published online 15 June 2005

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