Review
Nature Reviews Molecular Cell Biology 6, 872-881 (November 2005) | doi:10.1038/nrm1744
Article series: Developmental Cell Biology
Regulatory networks in embryo-derived pluripotent stem cells
Michele Boiani1 & Hans R. Schöler1 About the authors
Abstract
Mammalian development requires the specification of over 200 cell types from a single totipotent cell. Investigation of the regulatory networks that are responsible for pluripotency in embryo-derived stem cells is fundamental to understanding mammalian development and realizing therapeutic potential. Extracellular signals and second messengers modulate cell-autonomous regulators such as OCT4, SOX2 and Nanog in a combinatorial complexity. Knowledge of this circuitry might reveal how to achieve phenotypic changes without the genetic manipulation of Oct4, Nanog and other toti/pluripotency-associated genes.
- View At a Glance
Author affiliations
- Max-Planck Institute for Molecular Biomedicine, Department of Cell and Developmental Biology, Mendelstrasse 7/Von-Esmarch Strasse 56, 48149 Münster, Germany.
Correspondence to: Hans R. Schöler1 Email: schoeler@mpi-muenster.mpg.de
Published online 14 October 2005
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Induced pluripotency and cellular alchemyNature Biotechnology News and Views (01 Nov 2006)
Many ways to pluripotencyNature Biotechnology News and Views (01 Oct 2007)
See all 6 matches for News And ViewsRESEARCH
Cerebral blood flow response in adenosine 2a receptor knockout mice during transient hypoxic hypoxiaJournal of Cerebral Blood Flow & Metabolism Original Article
Maintenance of embryonic stem cell pluripotency by Nanog-mediated reversal of mesoderm specificationNature Clinical Practice Cardiovascular Medicine Article (01 Mar 2006)
See all 41 matches for Research
