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Signalling through nuclear receptors

Nature Reviews Molecular Cell Biology volume 3, pages 702–710 (2002)Cite this article

Abstract

A century ago, secretions from the pancreas were described as 'hormones', which we now know are secreted from all ductless glands. The development of various technologies has already contributed a great deal — and will undoubtedly offer more — to our understanding of their mode of action.

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Figure 1: Ernest Starling.
Figure 2: Frederick Banting and Charles Best with their first diabetic patient.
Figure 3: Principal structure–function characteristics of two classes of nuclear steroid/thyroid hormone/retinoid receptors.
Figure 4: The 1–2–3–4–5 rule.
Figure 5: A simplified model of a complex for RNA polymerase II (Pol II)-catalysed transcription.
Figure 6: Model to explain the dual effects of ecdysone on the induction and de-induction of serial chromosomal puffs during metamorphosis in Drosophila.

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Acknowledgements

I wish to thank Debbie Duthie for expert help in preparing this review.

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Authors and Affiliations

  1. the National Institute for Medical Research, Mill Hill, London, NW7 1AA, UK

    Jamshed R. Tata

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  1. Jamshed R. Tata
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DATABASES

LocusLink

androgen receptor

CBP

epidermal growth factor

growth hormone

insulin

Janus kinase

oestrogen receptor

PPAR

progesterone receptor

prolactin

RXR

thyroid hormone receptor

tyrosine aminotransferase

VDR

OMIM

diabetes

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Tata, J. Signalling through nuclear receptors. Nat Rev Mol Cell Biol 3, 702–710 (2002). https://doi.org/10.1038/nrm914

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