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The phosphatidylserine receptor: a crucial molecular switch?

Nature Reviews Molecular Cell Biology volume 2, pages 627–633 (2001)Cite this article

Abstract

The uptake and removal of necrotic or lysed cells involves inflammation and an immune response, due in part to processes that involve members of the collectin family, surface calreticulin and CD91. Clearance of apoptotic cells, by contrast, does not induce either inflammation or immunity. Could the phosphatidylserine receptor be the molecular switch that determines what the outcome will be?

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Figure 1: A proposed 'tether and tickle' mechanism for apoptotic cell uptake.
Figure 2: Phosphatidylserine on the surface of apoptotic cells.
Figure 3: Activation of immature dendritic cells.
Figure 4: The phosphatidylserine receptor as a key signalling receptor.
Figure 5: The role of collectins.
Figure 6: The phosphatidylserine receptor signalling switch.

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Author information

Authors and Affiliations

  1. the Department of Pediatrics, Program in Cell Biology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, 80206, Colorado, USA

    Peter M. Henson, Donna L. Bratton & Valerie A. Fadok

Authors
  1. Peter M. Henson
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  2. Donna L. Bratton
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  3. Valerie A. Fadok
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Related links

Related links

DATABASE LINKS

β1 integrin

β2 integrin

β3 integrin

CD14

ced-1

ced-2

ced-5

ced-12

ced-10

caspase-3

PKC-δ

PSR

LDLR

gas-6

TGF-β

interleukin-10

BMP

annexin V

elastase

emphysema

SP-A

SP-D

conglutinin

C1q

cC1qR

CD91

FURTHER INFORMATION

Henson lab

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Henson, P., Bratton, D. & Fadok, V. The phosphatidylserine receptor: a crucial molecular switch?. Nat Rev Mol Cell Biol 2, 627–633 (2001). https://doi.org/10.1038/35085094

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