Current Issue
July 2009 Vol 10 No 7
From the editors
p437 | doi:10.1038/nrm2725
Research Highlights
Cell signalling: An activating inhibitor? | PDF (143 KB)
p439 | doi:10.1038/nrm2724
In the news
Seeing red | PDF (97 KB)
p440 | doi:10.1038/nrm2710
Gene expression: UV-induced coupling | PDF (175 KB)
p440 | doi:10.1038/nrm2715
Apoptosis: Death by ubiquitylation | PDF (248 KB)
p441 | doi:10.1038/nrm2714
In brief
Cytoskeleton | Cell division | DNA damage response | PDF (117 KB)
p441 | doi:10.1038/nrm2723
Membrane trafficking: Lipid sorting and clustering | PDF (152 KB)
p442 | doi:10.1038/nrm2711
Protein degradation: Assembly from the base | PDF (158 KB)
p442 | doi:10.1038/nrm2719
In brief
Membrane trafficking | Protein translocation | Development | Cell death | PDF (124 KB)
p442 | doi:10.1038/nrm2722
Cell signalling: A fertility network | PDF (128 KB)
p443 | doi:10.1038/nrm2721
Journal Club
Building on the shoulders of giants | PDF (129 KB)
p444 | doi:10.1038/nrm2709
Gene expression: Complex interactions | PDF (179 KB)
p444 | doi:10.1038/nrm2716
Reviews
Collective cell migration in morphogenesis, regeneration and cancer
Peter Friedl & Darren Gilmour
p445 | doi:10.1038/nrm2720
The collective migration of cells as cohesive groups is prevalent during embryogenesis, organ development, wound repair and tumour invasion. The mechanisms that underlie different forms of collective cell migration are not well understood, but some general principles are emerging.
Dynamics and diversity in autophagy mechanisms: lessons from yeast
Hitoshi Nakatogawa, Kuninori Suzuki, Yoshiaki Kamada & Yoshinori Ohsumi
p458 | doi:10.1038/nrm2708
Studies of autophagy in yeast have identified a family of autophagy-related (Atg) proteins, which are required for membrane formation in autophagy. The dynamic assembly of Atg proteins into the pre-autophagosomal structure dictates the localization and activity of the autophagic machinery.
Proximal events in Wnt signal transduction
Stephane Angers & Randall T. Moon
p468 | doi:10.1038/nrm2717
The cytoplasmic and nuclear steps of the Wnt signalling pathway are fairly well understood. New insights into how secreted Wnt ligands stimulate receptor-mediated signalling have shown an unexpected diversity of Wnt receptors and further complexity in cellular responses.
Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis
Andrew J. Holland & Don W. Cleveland
p478 | doi:10.1038/nrm2718
The mitotic checkpoint is a cell cycle control mechanism that guards against chromosome missegregation and the subsequent production of aneuploid daughter cells. Although aneuploidy is a common characteristic of tumours, it can suppress tumorigenesis in certain genetic contexts and cell types.
Perspectives
Opinion
Clearing the way for mitosis: is cohesin a target?
Mitsuhiro Yanagida
p489 | doi:10.1038/nrm2712
In interphase, chromosomes are associated with proteins and RNAs that participate in many metabolic processes. During mitosis, these components might inhibit chromosome segregation or reduce its fidelity. The author proposes the existence of a molecular mechanism that eliminates unwanted components from mitotic chromosomes.
Science and society
Bio-art: the ethics behind the aesthetics
Frances Stracey
p496 | doi:10.1038/nrm2699
Bio-art — the crossover of art and biology — comes in many forms, including genetic portraits, transgenic animals and semi-living entities. But why do artists and scientists come together to collaborate on such projects, and what are the ethical implications of turning life into art?
