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Single proteins might have dual but related functions in intracellular and extracellular microenvironments

Nature Reviews Molecular Cell Biology volume 10, pages 228–234 (2009)Cite this article

Abstract

The maintenance of organ homeostasis and the control of an appropriate response to environmental alterations require the intimate coordination of cellular functions and tissue organization. An important component of this coordination could be provided by proteins that can have distinct but linked functions on both sides of the plasma membrane. We present a model that proposes that unconventional secretion provides a mechanism through which single proteins can integrate complex tissue functions.

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Figure 1: Models of linked intracellular and extracellular roles for molecules of dual topology or multiple function.
Figure 2: Distinct motifs mediate the different functions of epimorphin and syntaxin 2.

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Acknowledgements

Our work was supported by grants from the Office of Biological and Environmental Research of the Department of Energy (DE-AC03-76SF00098 and a Distinguished Fellow Award; to M.J.B.); the National Cancer Institute CA64786 (to M.J.B.), CA57621 (to M.J.B. and Z. Werb), CA122086 (to D.C.R.), CA128660 (to C. M. Nelson and D.C.R.) and the Breast Cancer Research Program of the Department of Defense (an Innovator Award; to M.J.B.).

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Authors and Affiliations

  1. Derek C. Radisky and Melody Stallings-Mann are at the Mayo Clinic Cancer Center, 4500 San Pablo Road, Jacksonville, Florida 32224, USA.,

    Derek C. Radisky & Melody Stallings-Mann

  2. Yohei Hirai is at the Department of Morphoregulation, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.,

    Yohei Hirai

  3. Mina J. Bissell is at the Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 977, Berkeley, California 94720, USA.,

    Mina J. Bissell

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Radisky, D., Stallings-Mann, M., Hirai, Y. et al. Single proteins might have dual but related functions in intracellular and extracellular microenvironments. Nat Rev Mol Cell Biol 10, 228–234 (2009). https://doi.org/10.1038/nrm2633

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