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Thomas Arnesen and colleagues discuss an emerging major role of one of the most common protein modifications, N-terminal acetylation, in shielding the proteome from degradation.
In this Tools of the Trade article, Khalid Ibrahim (Radenovic and Lashuel labs) describes a tool for the artificial intelligence (AI)-driven detection of cellular aggregates that bypasses the need for fluorescent labelling.
In this Tools of the Trade article, Hugo Damstra and Josiah Passmore (Kapitein Lab) describe GelMap, which introduces a fluorescent reference grid into the workflow of expansion microscopy experiments, thus enabling a visual readout of sample deformation.
The assembly of large protein–pigment photosystem supercomplexes relies on several assembly factors. Zhang et al. describe a novel assembly factor that evolved during the terrestrialization of land plants.
Ahna Skop and Karen Schindler describe a paper that found localized translation in mammalian embryos, demonstrating the importance of RNA transport for development.
Plant cells assemble a strong yet extensible primary cell wall consisting largely of polysaccharides. Emerging models of wall growth integrate physical properties such as mechanical strength and tension with cellular processes that govern wall loosening and expansion.
tRNA-derived small RNAs (tdRs) have long been considered mere intermediates of tRNA degradation. This Review discusses the biogenesis and regulation of tdRs and focuses on their emerging gene regulation roles in cell metabolism, immune responses, development and cancer.
Cell death can result from the activation of dedicated programmed cell death machineries or disruption of pro-survival mechanisms. This Review describes the different major mechanisms of cell death and discusses recent insights into their relevance to disease.
This Review discusses the emerging roles of long non-coding RNAs (lncRNAs) in the regulation of transcription, for example by controlling the expression of transcription factors. Some lncRNA loci function in trans, but most function in cis, through their own transcription or through the lncRNA transcripts themselves.
