Journal Clubs in 2024

Claire Durrant reminds us of the importance of studying the physiological roles of proteins and their aggregates to understand their roles in disease and inform therapies, discussing a 2008 paper on amyloid-β from the Arancio lab.

Stephanie Moon discusses findings that revealed that ribosome stalling can lead to the suppression of translation initiation in the brain, delaying the onset of neurodegeneration.

The first evidence that the formation of protein complexes is linked to protein synthesis was already provided in the early 1960s.

In the Journal Club, Fabrizio d’Adda di Fagagna remembers how the work of Judy Campisi changed our understanding of cellular senescence and its effect on physiology and ageing, shaping the future of this research field.

Imaging of fluorescently labelled nascent RNA in live cells enabled real-time observation of transcription of an endogenous gene.

Ahna Skop and Karen Schindler describe a paper that found localized translation in mammalian embryos, demonstrating the importance of RNA transport for development.

The story of a paper that established the concept of codon optimality and its connection with translation efficiency and mRNA decay.

Joana Vidigal reminds us of the first paper to report an endogenous role of the nucleolytic activity of the mammalian RNAi protein argonaute-2.