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Bracken and Goodall discuss why epithelial–mesenchymal transition (EMT) has so many regulators, but also consider whether many of these may be ‘false positives’.
Christine Mummery and Eric Anthony discuss some key changes to the ISSCR Guidelines for Stem Cell Research and Clinical Translation, which concern, among other experimental procedures, the culturing of human embryos, genome editing and mitochondrial replacement techniques.
In this Comment, the authors draw attention to the role of partial order in biomolecular condensates and propose that cooperative, ordered interactions between condensate components could underlie the formation and function of these diverse macromolecular assemblies.
Rippe and Papantonis suggest that intrinsically disordered regions in transcription-relevant factors underlie the formation of both ‘transcriptional condensates’ and ‘transcription factories’.
Michele Vendruscolo and colleagues propose that polyglutamine repeat expansion diseases could be caused by glutaminyl-tRNA depletion, leading to ribosome frameshifting and mistranslation of transcripts with specific characteristics.
Johnstone and Galloway contend that, to support complex patterning within engineered tissues, synthetic biology should be able to manage transcriptional noise.