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Cremer et al. show that the ubiquitin ligase RNF26 and vimentin-based intermediate filaments cooperate to control perinuclear ER membrane organization and thus facilitate recovery from ER stress.
Recent studies show that antigenic peptides are derived from the translation of precursor mRNAs. Robin Fåhraeus argues that it is therefore time to re-evaluate nuclear translation and its interesting implications.
The receptor-interacting serine/threonine-protein kinase 1 functions as a molecular switch to control cell survival, inflammation and cell death. Recent mechanistic studies shed light on the catalytic and non-catalytic roles and on the context-dependent functions of receptor-interacting serine/threonine-protein kinase 1 in health and disease.
Endoplasmic reticulum-associated protein degradation (ERAD) enables removal of aberrant or surplus proteins from the ER. ERAD represents a collection of independent processes exhibiting distinct yet overlapping selectivity for a wide range of substrates, enabling efficient quality control of membrane and secretory proteins.
Heat shock protein 90 (HSP90) is a chaperone that facilitates protein folding. In diseased cells, HSP90 and its co-chaperones form oligomers, known as epichaperomes, that confer aberrant scaffolding and holding functions onto the chaperone.
In this Tools of the Trade article, Roffay and Mercier (from the Roux lab) describe the development of fluorescent Flipper probes that allow measurement of membrane mechanics in vivo.
Vascular endothelial growth factor A (VEGFA) is an important regulator of angiogenesis. Increasing knowledge of its role in pathophysiology has culminated in the wide use of anti-VEGFA agents in oncology and in the treatment of neovascular eye disorders, and has opened avenues for promoting tissue vascularization in regenerative medicine.
Cycles of stretch and compression, such as during cell migration through tissues, lead to stabilization of microtubules owing to redistribution of the plus-end-binding protein CLASP2 along microtubule lengths.
Transcription factors bind RNA through an Arg-rich motif; these interactions potentially promote transcription and development, and their dissociation can contribute to disease.
All aspects of gene regulation involve RNA helicases, which bind or remodel RNA and RNA–protein complexes. Recent data establish a link between helicase structure, mechanism of function and biological roles, including in diseases such as cancer and neurological disorders, with implications for the design of small-molecule inhibitors.
BCL-2 proteins fulfil important functions in cell death as initiators, guardians and executioners of mitochondrial outer membrane permeabilization. Recent findings demonstrating complex interactions among BCL-2 proteins set forth a comprehensive model of BCL-2 action.
During cellular stresses, the mRNA internal 7-methylguanosine (m7G) modification is bound by QKI-7, which regulates the stability and/or translation of the mRNAs by sequestering them in stress granules.
In this Tools of the Trade article, William Leineweber (from the Fraley lab) describes the set-up of an integrated biophysical imaging platform that allows researchers to assess the interactions between cells and the surrounding extracellular matrix.
Nucleobase modifications are prevalent in eukaryotic mRNA and are broadly required for post-transcriptional gene regulation. The most studied mRNA modification is N6-methyladenosine (m6A), yet various other modifications are now being identified and studied. This Review discusses the emerging mechanisms and roles of these non-m6A modifications.
In this Tools of the Trade article, Edoardo José Longarini and Helen Dauben (from the Matić lab) describe the development and applications of mono-ADP-ribosylation antibodies and peptides.
