Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Andrew Pollard describes a 1921 study by George Heist and colleagues that pointed to antibody as a correlate of protection against meningococcal disease.
Two studies have characterized a distinct molecular signature of intratumoral CD4+regulatory T cells from various tumours that correlates with cancer prognosis.
This Review provides a comprehensive overview of the early airway immune responses to infections. The authors discuss the stepwise engagement of distinct tiers of effector functions and how early airway immune responses are influenced by factors such as the environment, obesity and ageing.
This Review provides a comprehensive overview of the influences on human immune system variation. Systems immunology analyses have revealed that variations between individuals are mainly due to non-heritable influences such as age, sex, microbiota and the environment.
Dendritic cells (DCs) shape tolerogenic and pro-inflammatory immune responses by presenting antigens to T cells; their ability to localize in peripheral tissues and secondary lymphoid organs is crucial for these functions. This Review describes the different migratory pathways employed by subsets of DCs from distinct tissue sites, detailing their mechanistic basis and importance for maintaining health.
This Review discusses the contribution of different cytokine networks to inflammation in the central nervous system (CNS). In neuroinflammatory diseases such as multiple sclerosis, CNS-invading leukocytes produce many of the cytokines that are associated with disease. By contrast, in Alzheimer disease and other neurodegenerative diseases, tissue-resident cells are the main source of pathological cytokines.
Understanding the gradual development of disease in patients with seropositive rheumatoid arthritis offers new opportunities for prevention and early therapy.
