Volume 13 Issue 7, July 2013

IL-1α fosters autoinflammation in the absence of fully active SH2 domain-containing protein tyrosine phosphatase 1 (SHP1).

Neutrophil clearance controls the circadian release of haematopoietic progenitor cells from the bone marrow in the steady state.

Autophagy is an epithelial cell-intrinsic innate immune mechanism that protects against the dissemination of invasive intestinal bacteria.

The switch to aerobic glycolysis in activated CD4⁺T cells is required for full effector function but not for proliferation or survival.

Group 3 ILCs promote tolerance to commensal bacteria by inhibiting adaptive T cell responses.

Ubiquitylation of MHC class II molecules by DC-expressed MARCH1 is required for thymic T_Regcell development.

In this Review, the authors discuss the molecular mechanisms that enable B cells to internalize, process and present antigens on MHC class II molecules to CD4⁺T cells. They focus on the importance of cytoskeletal rearrangements and the establishment of polarity in B cells for these processes.

This article describes recent progress in delineating the factors that contribute to spontaneous HIV-1 immune control, with the ultimate aim of translating these studies into clinical strategies to induce a 'functional cure' of HIV-1 infection.

The transcription factors BATF (basic leucine zipper transcription factor ATF-like), BATF2 and BATF3 have unique positive transcriptional activities in the development and the function of dendritic cells, B cells and T cells, which are mediated through molecular interactions with interferon-regulatory factor 4 (IRF4) and IRF8.

Coronins were first characterized on the basis of their interactions with the actin cytoskeleton and were later linked to immune dysfunction. In this short, focused Review, the authors discuss the emerging roles of coronins in immune cell signalling.

Primary antibody deficiencies (PADs) are the most common form of hereditary immunodeficiencies. Here, the authors discuss how recent progress in the genetic and molecular understanding of PADs has illuminated previously unappreciated aspects of B cell function and has helped to explain the broad range of pathologies linked to PADs.

The mechanisms underlying the antiviral activity of type I interferons (IFNs) are still unclear, but IFNα has long been used in the treatment of chronic hepatitis C (CHC). While reviewing the history of IFNα-based CHC treatment, Markus H. Heim highlights the remaining questions and discusses the future challenges of IFN-based therapies.