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This Review from Gabrilovich and colleagues discusses our current understanding of the development and functions of myeloid-derived suppressor cells (MDSCs). Recent work has identified unique metabolic properties and gene expression patterns in MDSCs that could help in the development of new therapies for cancer and autoimmunity.
This Review provides an overview of haem oxygenase 1 (HO-1) for immunologists, including its roles in iron metabolism and antioxidant defence, and the impact of HO-1 induction in specific immune cell populations. The authors highlight the therapeutic potential of HO-1 induction for treatment of chronic inflammatory and autoimmune diseases.
Periodontitis has been causally linked to the development of other chronic inflammatory diseases outside the oral mucosa. In this Review, George Hajishengallis and Triantafyllos Chavakis consider the molecular basis of these links.
In this Review, Zengeler and Lukens consider how innate immune signalling pathways contribute to healthy brain development and the implications for neurodevelopmental disorders.
In this Review, Lloyd and Hewitt describe our contemporary understanding of the airway epithelial cell landscape. They highlight the new epithelial cell types that have been recently discovered and explain how epithelial cells interact with the immune and nervous systems to shape immunity in the airways.
This Review by Harschnitz and Studer explains how human pluripotent stem cell technology can be used to explore antiviral immunity in the central nervous system. Such technology could help us to identify new therapies for a range of central nervous system viral infections and to uncover the mechanisms behind the central nervous system complications associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
