News & Comment

MTORC1-dependent macrophage proliferation and glycolysis drive granuloma formation in sarcoidosis.

Pseudogenization of a singleSalmonellaeffector protein gene facilitates pathogen hijacking of dendritic cells to spread systemically.

During systemic infection interleukin-22 can limit the availability of iron by promoting increased production of haem scavengers.

CYP1 enzymes expressed by intestinal epithelial cells metabolise AHR ligands in the gut to regulate intestinal immune responses.

A T cell receptor signalling inhibitor shows efficacy in autoimmune diseases without affecting immune responses to pathogens.

Chewing induces the accumulation of T helper 17 cells in the mouth.

Michael McHeyzer-Williams describes a 1998 study by Avi Kupfer and colleagues that transformed the view of cognate T helper cell–B cell crosstalk.

Increased expression of inflammasome-related gene modules in older individuals correlates with nucleotide metabolism dysfunction, IL-1β production and cardiovascular disease.

Plasma cells accumulate in the ageing thymus and may provide protection against viral infections.

Interleukin-33 is a key driver of type 2 immunity in the developing neonatal lung of mice both in the steady state and in response to allergen exposure.

Different microbial stimuli lead to specific metabolic programmes in activated human monocytes.

NLRC3 protects against colorectal cancer by suppressing the proliferation of intestinal epithelial cells through inhibition of the PI3K–AKT–mTOR pathway.