News & Comment

Michael McHeyzer-Williams describes a 1998 study by Avi Kupfer and colleagues that transformed the view of cognate T helper cell–B cell crosstalk.

Andrew Pollard describes a 1921 study by George Heist and colleagues that pointed to antibody as a correlate of protection against meningococcal disease.

Alan Sher describes a 2002 paper by Martien Kapsenberg and Pawel Kalinski that provided evidence for the conditioning of DCs by microbial compounds to promote T_H1 or T_H2 cell responses.

Gwendalyn Randolph describes a 1981 paper by Ross Gerrity that stimulated her career focus on the trafficking of mononuclear phagocytes.

Gail Bishop describes a 1985 study by Antonio Lanzavecchia that changed our understanding of B cell–T cell interactions.

Steven Ziegler describes a 1986 study by Mossmannet al. that defined two subsets of T helper cells on the basis of their activities.

Akiko Iwasaki describes a 1980 study by Halleret al. that revealed a limitation of using inbred mice to study antiviral responses.

Tracy Hussell describes a 2003 study by Chenet al. that pioneered the concept of heterologous immunity.

Kiyoshi Takeda describes a 2009 paper by Maslowskiet al. that provides the first evidence of a link between microbiota-derived metabolites and human health.

Fabienne Mackay describes a 2011 paper by Wineret al. that observed an effect of diet on the B cell repertoire.

Peter Doherty describes the 1962 paper by Jim Gowans that characterized lymphocyte-mediated immunity.

Sarah Gaffen describes a 2006 paper by Toyet al. that elucidated the subunit composition of the receptor for IL-17.

Ron Germain describes two seminal papers by Marc Jenkins and colleagues that introduced new techniques for analysis of the T cell repertoire.

Ruslan Medzhitov describes a 2002 paper by Craig Thompson and colleagues that brought the concept of Warburg metabolism to lymphocytes.

John O'Shea describes a 2000 paper by Roggeet al. that was the first to compare the transcriptomes of human T_H1 cells and T_H2 cells.

Jeffrey Pollard describes a 2003 study by Enzleret al. that identified the immune response against bacteria as preventing chronic inflammation-associated tumour development.

Allan Mowat describes a 2005 study that identified the ability of CD103⁺dendritic cells to imprint T cells with gut-homing specificity.