Review
Nature Reviews Immunology 7, 610-621 (August 2007) | doi:10.1038/nri2132
Focus on: Immune tolerance
Tolerogenic dendritic cells and the quest for transplant tolerance
Adrian E. Morelli1,2 & Angus W. Thomson1,2 About the authors
Abstract
In recent years, there has been a shift from the perception of dendritic cells (DCs) solely as inducers of immune reactivity to the view that these cells are crucial regulators of immunity, which includes their ability to induce and maintain tolerance. Advances in our understanding of the phenotypical and functional plasticity of DCs, and in our ability to manipulate their development and maturation in vitro and in vivo, has provided a basis for the therapeutic harnessing of their inherent tolerogenicity. In this Review, we integrate the available information on the role of DCs in the induction of tolerance, with a focus on transplantation.
- View At a Glance
Author affiliations
- Thomas E. Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA. Email: morelli@imap.pitt.edu
- Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA. Email: thomsonaw@upmc.edu
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Plasmacytoid DCs and T reg cells: casual acquaintance or monogamous relationship?Nature Immunology News and Views (01 Jun 2006)
When ligand becomes receptor?tolerance via B7 signaling on DCsNature Immunology News and Views (01 Nov 2002)
See all 4 matches for News And ViewsRESEARCH
Tolerization of dendritic cells by T S cells: the crucial role of inhibitory receptors ILT3 and ILT4Nature Immunology Article (01 Mar 2002)
See all 34 matches for Research