Access
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
Review
Nature Reviews Immunology 7, 365–378 (1 May 2007) | doi:10.1038/nri2072
New developments in Fc|[epsi]|RI regulation, function and inhibition
&
Abstract
The high-affinity Fc receptor for IgE (Fc|[epsi]|RI), a multimeric immune receptor, is a crucial structure for IgE-mediated allergic reactions. In recent years, advances have been made in several important areas of the study of Fc|[epsi]|RI. The first area relates to Fc|[epsi]|RI-mediated biological responses that are antigen independent. The second area encompasses the biological relevance of the distinct signalling pathways that are activated by Fc|[epsi]|RI; and the third area relates to the accumulated evidence for the tight control of Fc|[epsi]|RI signalling through a broad array of inhibitory mechanisms, which are being developed into promising therapeutic approaches.
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
