FIGURE 3 | Inhibitory signals for mast-cell mediator release induced by FcRI aggregation.

The inhibitors include ligands of immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptors, such as FcRIIb, gp49B1, signal regulatory protein- (SIRP), human leukocyte immunoglobulin-like receptor, subfamily B, member 4 (LILRB4) and CD300a, the anti-inflammatory cytokines transforming growth factor- (TGF) and interleukin-10 (IL-10), CD200 and the intracellular signalling molecules, such as LAB (linker for activation of B cells; also known as non-T-cell activation linker, NTAL) or RABGEF1 (RAB guanine nucleotide exchange factor 1). Most of the data derive from in vitro experiments or from animal models. ITAM, immunoreceptor tyrosine-based activation motif; R, receptor; SHIP, SH2-domain-containing inositol polyphosphate 5' phosphatase; SMAD, mothers against decapentaplegic homologue.

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