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The transcriptional repressor B-lymphocyte-induced maturation protein 1 (BLIMP1) has a pivotal role in the terminal differentiation of antibody-secreting cells. In this Progress article, Stephen Nutt and colleagues highlight the most up-to-date findings about the role of BLIMP1 in the final stages of lymphocyte maturation.
The thymus is a specialized environment that controls the development of T cells. In this article, Graham Anderson and colleagues review the role of the thymic stroma in controlling T-cell development, focusing on the development and function of thymic epithelial cells.
This Review describes the journey taken by the MHC-class-I-like CD1 molecules, detailing their assembly, intracellular trafficking and loading with lipid antigens. By taking distinct routes, the different CD1-family members ensure that each intracellular compartment is surveyed for their lipid cargo.
How does a T cell recognize an allogeneic antigen? How does it compare with the conventional recognition of self antigen? Why does alloreactivity exist? Here, Paul Allen and Nathan Felix discuss these questions in the context of recent advances in our understanding of allorecognition.
Helminths infect millions of people worldwide. In this Review, William Gause and colleagues outline the current understanding of immune responses against helminth infections, focusing on results obtained in mouse models of infection withHeligmosomoides polygyrus and Schistosoma mansoni.
This Review describes the recent insights into the receptors and signalling pathways that are required for the engulfment of apoptotic cells, with particular emphasis on the 'find-me' and 'eat-me' signals expressed on apoptotic cells.
In this Opinion article, the authors propose that the immunological process that underlies type 1 diabetes is relapsing–remitting in nature; they highlight the supporting evidence and the remaining controversies, and discuss the possible therapeutic implications of their hypothesis.