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In this Comment article, Becker and colleagues consider how the excessive release of reactive oxygen species by neutrophils may perpetuate red blood cell dysfunction, thrombosis and tissue damage in severe cases of COVID-19.
The ATP–adenosine pathway plays an important role in modulating innate and adaptive immune responses in the tumour microenvironment. Here, the authors focus on CD39, a key enzyme in the ATP–adenosine pathway, and examine immunotherapeutic strategies that target it.
In this Progress article, Zeyu Chen and E. John Wherry summarize early reports of the T cell responses observed in patients with COVID-19, emphasizing how different immune response characteristics in different patients may reflect a spectrum of disease phenotypes.
Bile acid from intestinal symbiotic bacteria helps to resist alphavirus infection by supporting type I interferon responses by plasmacytoid dendritic cells, which in turn limit the permissiveness of circulating monocytes to viral infection.
Multi-omics profiling of endothelial cells, epithelial cells and fibroblasts from 12 mouse organs was used to create an atlas of immune gene activity in structural cells.
In this Viewpoint, six leading experts consider the ways in which the microbiota can influence immune responses to cancer. Immunotherapies have been revolutionary in the treatment of cancer, but will we one day further increase their efficacy with microbiota-derived drugs?
A study by Lowe, Sadelain and colleagues demonstrates that senolytic CAR T cells can reverse pathology in mouse models of senescence-associated diseases.