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This Review focuses on the roles of γδ T cells in tissue homeostasis and immune surveillance. The authors discuss exciting new studies showing how γδ T cells can regulate diverse physiological responses in tissues, ranging from thermogenesis in adipose tissue to remodelling at neuronal synapses.
Neurological symptoms are increasingly being observed in patients with COVID-19; this Comment article considers whether cross-reactive antibodies might contribute to the pathology associated with SARS-CoV-2 infection.
How does the discovery of SARS-CoV-2 cross-reactive T cells in unexposed individuals change our understanding of the COVID-19 pandemic? In this Perspective, the authors provide a thought experiment to explain why the discovery of cross-reactive T cells may affect disease severity in individuals, but is unlikely to change our estimate of the herd immunity threshold.
Memory B cells are critically important for the formation of protective immunity following infection or vaccination, and a better understanding of these cells may inform strategies to overcome hurdles in the development of effective vaccines. This Review discusses the signals and transcription factors that regulate the development and function of germinal centre-derived memory B cells.
This Web Watch introduces the VaC tracker, a web resource that features an overview of the COVID-19 ‘vaccine landscape’, a clinical trials database and a ‘living review’ that distils the results of vaccine trials as they become available.
A population of meningeal γδ T cells regulates anxiety-like behaviour and threat avoidance in mice through IL-17a production, which signals to neurons in the medial prefrontal cortex.
A transcription factor network triggered by Notch signalling in the thymus guides proliferating, multipotent progenitor cells into the T cell pathway. This Review describes how these factors work to establish regulatory target specificity, epigenomic impact and irreversibility for T cell identity.
Here, the authors explore how the modern way of life increases the risk of allergy and asthma, in particular by affecting the formation and diversity of the microbiota in early life. Understanding these changes highlights strategies for allergy prevention.
For this Viewpoint, Nature Reviews Immunology asked the presidents of 16 immunology societies from around the world to discuss how their society and its members responded to the COVID-19 pandemic. Their answers highlight the incredible contributions that immunologists around the globe have made following the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
During the current COVID-19 pandemic, the concept of herd immunity has become a topic of much debate. This Comment examines the factors that determine it, discusses how far we have come and considers what it will take to reach herd immunity safely.
Genetic models of dendritic cell (DC) development in mice have aided our understanding of the redundant and non-redundant functions of DC subsets and enabled translation of these findings to human DCs.
Two papers report the development of novel systemic agonists of stimulator of interferon genes (STING) and show that these boost antitumour immunity in mouse models of cancer
