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Wieland et al. report that the tumour microenvironment of human papillomavirus (HPV)-positive head and neck squamous cell carcinomas contains HPV-specific B cells that actively secrete HPV-specific antibodies.
In February 2021, Nature Reviews Immunology launches the first of its monthly ‘Preprint Watch’ columns. Here, we explain the rationale for our coverage of preprints and the precautions we have taken to guard against their improper use.
A recent study in Science Immunology describes a new approach to selectively eliminate pathogenic CD4+ T cells in inflammatory bowel disease by activating them in the presence of metabolic checkpoint inhibition.
Here, Veldhoen and Simas discuss why immunity to SARS-CoV-2 in populations may ultimately be driven by the endemic presence of the virus and not rely on continued mass vaccination programmes.
This Review by Harschnitz and Studer explains how human pluripotent stem cell technology can be used to explore antiviral immunity in the central nervous system. Such technology could help us to identify new therapies for a range of central nervous system viral infections and to uncover the mechanisms behind the central nervous system complications associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.