Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Nonalcoholic fatty liver disease (NAFLD) can affect both adults and children. As the incidence of obesity continues to increase in children and adolescents, so too does the occurrence of NAFLD in these pediatric patients. Here, Alisi and colleagues provide an overview of pediatric NAFLD, describing the epidemiology, pathogenesis, diagnosis and treatment of these young patients.
Despite enthusiastic efforts using the latest advanced molecular technologies, no specific universal genetic alteration has been found in hepatocellular carcinoma (HCC). The application of whole-genome sequencing using next-generation sequencing technologies is starting to clarify the intraindividual and intratumoral diversity in genomic alterations in HCC. A new sequencing era in HCC has begun.
Important advances have been made in the management of IBD in 2011. Research has focused on optimizing the currently available therapies and taking a more tailored approach to each individual patient.
Nonvariceal upper gastrointestinal bleeding (UGIB) is a major cause of morbidity and mortality worldwide, and despite improvements in the management of patients with this condition, there have only been moderate improvements in mortality rates. This Review discusses the diagnosis of UGIB and describes the optimal management of patients with this condition, in accordance with the current consensus recommendations and contemporary literature. The authors examine endoscopy, management of bleeding and pharmacological therapy for patients with UGIB.
