A genome-wide association study aimed to identify novel single nucleotide polymorphisms (SNPs) associated with an increased risk of Barrett oesophagus as well as validate previously reported associations. Genotype analysis was performed in 10,158 patients with Barrett oesophagus and 21,062 controls. Two new SNPs were identified in genes that encode transcription factors involved in thoracic, diaphragmatic and oesophageal development, or proteins involved in the inflammatory response.
References
Palles, C. et al. Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus. Gastroenterology 10.1053/j.gastro.2014.10.041
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Two new polymorphisms associated with Barrett oesophagus. Nat Rev Gastroenterol Hepatol 12, 2 (2015). https://doi.org/10.1038/nrgastro.2014.211
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DOI: https://doi.org/10.1038/nrgastro.2014.211