A randomized trial investigating the potential of resistant starch in preventing colorectal cancer (CRC) has found no protective effect. No significant difference was found between patients given resistant starch (n = 463) and those given placebo (n = 455) in the time to first CRC (HR 1.40, P = 0.26) or after study completion at 2 years (HR 1.09, P = 0.80). Resistant-starch supplementation does not, therefore, seem to emulate the protective effect of diets rich in dietary fibre against CRC.
ORIGINAL RESEARCH PAPER
Mathers, J. C. et al. Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial. Lancet Oncol. doi:10.1016/S1470-2045(12)70475-8
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Resistant starch supplement has no detectable benefit against colorectal cancer. Nat Rev Gastroenterol Hepatol 10, 2 (2013). https://doi.org/10.1038/nrgastro.2012.230
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DOI: https://doi.org/10.1038/nrgastro.2012.230
