Nature Reviews Gastroenterology & Hepatology

Volume 14, No 5 May 2017



Gut microbiome as a clinical tool in gastrointestinal disease management: are we there yet?

Eamonn M. M. Quigley

Gut microbiota research has rapidly evolved, but has yet to translate fully to the clinic. In this Perspectives, Eamonn Quigley explores whether the gut microbiota could be used as a clinical tool in gastrointestinal disease, providing a note of caution to the hype.

Front cover of the current issue of Nature Reviews Gastroenterology and Hepatology

2015 2-year Impact Factor 14.435 Journal Metrics 2-year Median 8

Advance Online Publication


How to stomach an epigenetic insult: the gastric cancer epigenome

Nisha Padmanabhan, Toshikazu Ushijima & Patrick Tan

Gastric cancer is a deadly malignancy and accumulating evidence suggests that epigenetic abnormalities promote carcinogenesis. Here, the authors summarize the gastric cancer epigenome, highlighting key advances from studies of DNA methylation and histone modifications, and how these findings might lead to therapeutic opportunities.

Advance Online Publication


Post-infectious IBS, tropical sprue and small intestinal bacterial overgrowth: the missing link

Uday C. Ghoshal & Kok-Ann Gwee

Acute gastroenteritis precipitates post-infectious IBS in 10–30% of patients. In this Perspectives, Ghoshal and Gwee discuss evidence of overlap between post-infectious IBS, tropical sprue (which can also develop after acute gastroenteritis) and small intestinal bowel overgrowth, and argue that greater understanding of the links between these conditions will improve understanding of IBS pathogenesis.

Advance Online Publication

News and Views

Paediatrics: Are human milk oligosaccharides the magic bullet for necrotizing enterocolitis?

Michael S. Caplan

There have been no major improvements in the prevention or treatment of necrotizing enterocolitis (NEC) over the past several decades, and therefore a 'magic bullet' is urgently needed. However, new data demonstrate that disialyllacto-N-tetraose levels in breast milk can predict the risk of NEC, and these findings might provide a strategy for successful intervention.

Advance Online Publication


Helicobacter pylori infection and antibiotic resistance: a WHO high priority?

Bich N. Dang & David Y. Graham

The WHO listed Helicobacter pylori among 16 antibiotic-resistant bacteria that pose the greatest threat to human health. Given the alarmingly high H. pylori antibiotic resistance rates, antibiotic stewardship programmes need to be developed and implemented. Future research should explore provider and systems-level barriers to H. pylori antibiotic susceptibility testing.


Nature Reviews cover competition 2018

Wanted: eye-catching images to feature on the covers of our 2018 issues of the clinical Nature Reviews titles. We are offering the opportunity for your image to appear on the cover throughout 2018! The owners of the chosen images will also receive a one year personal online subscription to the relevant journal and a print of their cover as a thank you. Good luck and we look forward to seeing your images!

Cancer Evolution

In this collection, the cancer editorial community of the Nature journals presents the most recently published articles on cancer evolution. The topic is discussed from different complementary angles (preclinical, translational and clinical), and across a broad range of tumour types.

Key Advances in Medicine eBook

The world of medicine is fast-paced and ever-changing; the Key Advances in Medicine eBook is bursting with information for medical students, physicians and clinical researchers wishing to keep up with the most significant medical breakthroughs of the past year. This eBook, which is free to download for registered users, contains 45 articles summarizing the key clinical and biomedical studies published in 2016 and highlighting the trends to watch out for in 2017. The articles are written by international experts who identify the top ground-breaking research papers within their speciality.

Article series on cell & developmental biology in the digestive system

In this article series, Nature Reviews Gastroenterology & Hepatology explores different cell biology and developmental pathways involved in gastrointestinal health and disease, the role of stem and progenitor cells in tissue development and regeneration and recent advances in bioengineering, which might shape clinical approaches in the near future.

Optical imaging collection

The evolution of optical technologies for diagnostic imaging has revolutionized the understanding, detection and treatment of disease. This Collection of recent content published in Nature journals brings together advances in the field and highlights their impact in the clinic.

Fibrosis collection

This collection consists of Reviews and Research articles from several Nature journals, describing the latest advances in fibrosis research in various organs, including the liver, kidney, heart, skin and lung. It also includes relevant News and Opinion articles and additional content, including a selection of peer-reviewed procedures from Nature Protocols, and a PrimeView, which summarizes the main features of systemic sclerosis.

Focus on Coeliac disease & gluten sensitivity

Awareness and understanding of gluten-related disorders (including coeliac disease and noncoeliac gluten sensitivity) has improved over the past few decades, with insights into the immunopathogenesis and genetics, as well as in serology, diagnosis, clinical features and management. These specially commissioned articles, written by key opinion leaders in the field, highlight new understanding of coeliac disease and gluten sensitivity, including pathogenesis, overlap with other autoimmune diseases, gluten-related disorders in childhood, extraintestinal manifestations, refractory disease, practical insights into a gluten-free diet and the debate around noncoeliac gluten sensitivity.

A decade in medicine eBook

The past 10 years has seen great advances in the understanding and treatment of human disease. For expert perspectives on the most important breakthroughs, don't miss the A Decade in Medicine eBook. In this special collection of 47 articles—commissioned to celebrate the 10th anniversary of the launch of the clinical Nature Reviews journals—leading experts highlight the most important advances in eight medical specialties between 2004 and 2015, and comment on future developments in their fields. The A Decade in Medicine eBook is FREE to download for registered users.

Nature Reviews Gastroenterology & Hepatology is on Twitter. Follow us to keep up-to-date with the latest content.

Nature Reviews is on Facebook! Like us for regular updates on new content across all the Nature Reviews journals.

Nature Reviews Gastroenterology & Hepatology was previously published as Nature Clinical Practice Gastroenterology & Hepatology.


Extra navigation


Subscribe to Nature Reviews Gastroenterology and Hepatology