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The interval colorectal cancer rate is a robust indicator of the quality and effectiveness of a screening programme, enabling the identification of unmet requirements and development of specific strategies to resolve them. A recent study demonstrated the use of interval cancer as an indicator to target quality improvement of colonoscopy in a screening programme.
For many patients with Hirschsprung disease, the underlying pathogenic mechanisms are unknown. A new study using a novel line of transgenic mice and tissue from patients with Hirschsprung disease suggests that overproduction of collagen VI could contribute to pathogenesis and the increased incidence of Hirschsprung disease in patients with Down syndrome.
Spondyloarthritis (SpA) is the most common extraintestinal manifestation of IBD. SpA symptoms are not always recognized in patients with IBD. Subsequently, patients with symptoms of SpA can be underdiagnosed, with effective treatment delayed. Cooperation between gastroenterologists and rheumatologists is necessary and, ideally, an integrated management of these patients should be adopted.
Bariatric surgery is efficient in achieving weight loss in severe obesity, but associated anatomical or mechanical alterations might also affect oesophageal function. Each type of surgery has its own risks and benefits when it comes to pre-existing or the potential development of postoperative oesophageal disorders. Here, the three most common types of bariatric surgery and their respective influences on oesophageal function are discussed.
IBD is a chronic inflammatory disorder of the gut and major progress has been made in understanding the underlying mechanisms that mediate the disease. Here, the authors provide a comprehensive overview of the immunopathogenesis of IBD, discussing known and emerging pathogenic factors that include immune and nonimmune events.
Oropharyngeal dysphagia is a common swallowing disorder. In this Review, Rommel and Hamdy describe the most frequent manifestations of oropharyngeal dysphagia, including potential causes and complications. They also provide a comprehensive overview of the techniques available to diagnose this condition.