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Two studies analysing ancient hunter-gatherer genomes report detailed insights into the history and interactions of West Eurasian hunter-gatherer groups and highlight the genetic replacement of entire Ice Age populations.
Sérgio Pena discusses a 2019 study by Gruhn et al., which showed that meiotic chromosome segregation errors originating in oocytes determine the curve of female fertility in humans.
Selene Fernandez-Valverde recalls a seminal publication by Jacob and Monod to showcase how thoughtful reasoning and extrapolation of limited observations can provide meaningful insights into complex systems.
This Review surveys the known mechanisms of communication between RBPs and their effectors and their roles in reducing the complexity of RNA networks. The authors review the emerging roles of RBP–effector interactions in the control of RNA processing and regulation of biological outcomes, and their contribution to human health and disease.
In this Review, the authors discuss our latest understanding of the spatial aspects of cancer evolution, including the roles of cancer subclonal structure, tissue architecture, and interactions between cancer cells and diverse cell types of the microenvironment at local and distant sites.
In this Review, the authors describe how advances in comparative primate genomics — complemented by multi-layered omic resources and primate cell systems — are providing insights into the evolution of primates and the genetic underpinnings of key traits of developmental and biomedical importance.
Environmental pollutants have been shown to disrupt molecular mechanisms underlying common complex diseases. The authors review the interplay of environmental stressors with the human genome and epigenome as well as other molecular processes, such as production of extracellular vesicles, epitranscriptomic changes and mitochondrial changes, through which the environment can exert its effects.
