Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Diverse types of RNA in various species are modified by methylation to formN6-methyladenosine (m6A). This Review describes how progress in the characterization of m6A distributions and of proteins that 'write', 'erase' and 'read' this mark is revealing roles for reversible m6A methylation in dynamic gene expression control.
This Review describes how genomic technologies are providing novel insights intoMycobacterium tuberculosis, which is the causative agent of human tuberculosis. There has been progress in understanding the ancient evolutionary history of human-adapted M. tuberculosis, mutations underlying strain diversity and drug resistance, and the host–pathogen molecular interactions.
Programmable nucleases — including ZFNs, TALENs and RGENs derived from the prokaryotic CRISPR–Cas system — enable targeted high-precision genome engineering. This Review summarizes current knowledge of nuclease-specific features, individual pros and cons, and approaches to improve the efficiency of these enzymes to help researchers to choose the most appropriate tool for various genome editing experiments and applications.
This Review discusses the principles and applications of significance testing and power calculation, including recently proposed gene-based tests for rare variants.
Whole-genome assemblies of humans and non-human primates are yielding data on the evolutionary origins of the human genome, as well as insights into genetic similarities and differences between species used as models for disease-related research. This Review discusses current knowledge and opportunities for comparative primate genomics created by recent advances in genome sequencing technologies.
