Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Revealing genetic influences on metabolic phenotypes is important in further understanding the aetiology of many complex diseases. Here, the authors introduce study design considerations and applications for genome-wide association studies with metabolic traits.
Growing evidence is implicating non‑B-form DNA structures in processes related to DNA stability and function, including replication and transcription. In particular, genomic studies are suggesting that sequences that could form G-quadruplex structures are widespread, so there is a need to improve our understanding of these structures.
Recent advances in genetic technologies have progressed the understanding of the biological pathways mediating the control of germ cell development. In this Review the genes and strategies involved inDrosophila melanogaster, Caenorhabditis elegansand mouse germline development are compared and contrasted.
The advance of DNA-sequencing technologies is allowing the investigation of cancer genome evolution at an unprecedented resolution. This article presents recent insights into cancer genome heterogeneity and adaptation gained from the application of novel strategies.
Genome-wide association studies (GWASs) of mice provide an alternative means of identifying genes and genetic variants that are important for human physiology and disease. This Review describes the various resources and strategies for GWASs of mice, emphasizing their advantages and pitfalls relative to human studies.
We asked five experts their opinions on issues that arise from new clinical tests that are based on next-generation sequencing. Crucial gaps in infrastructure need to be addressed for the results of these tests to be optimally handled.
