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Genome-wide linkage and association studies have reliably implicated a growing number of genes in susceptibility to addiction. An emerging theme is the substantial overlap in loci that are associated with addiction to multiple substances.
Fox genes encode a large and ancient family of transcriptional regulators with a wide range of biological functions. This article describes the evolution of this family, its importance in development and disease, and the basis of its functional diversification.
The last few years have seen extensive efforts to catalogue human genetic variation and elucidate its relationship to phenotypes, especially disease. Important challenges lie ahead in this area, particularly in relation to the contribution of rare and copy number variants.
Transcription factors (TFs) are essential for gene expression, but very little is known about the majority of human TFs. This Analysis article provides a manually curated repertoire of sequence-specific human TFs as a foundation for future research, and examines patterns of TF expression and conservation.
The success of genome wide association (GWA) studies raises the hope that disease-associated markers will be useful in predicting disease risk. However, the metrics used to report effect sizes in GWA studies are not useful for determining the accuracy of genetic profiles.
Diverse lines of evidence link replication timing with epigenetic marks and transcriptional potential. The authors of this article propose a model in which mechanisms that bring about coordinated changes in replication timing also provide a platform for reprogramming the epigenome.
