Applications of next–generation sequencing
The power of high–throughput DNA sequencing technologies is being harnessed by researchers to address an increasingly diverse range of biological problems. The scale and efficiency of sequencing that can now be achieved is providing unprecedented progress in areas from the analysis of genomes themselves to how proteins interact with nucleic acids. This series highlights the breadth of next–generation sequencing applications and the importance of the insights that are being gained through these methods.
2009
Advance online publication November 24 2009
Prokaryotic transcriptomics: a new view on regulation, physiology and pathogenicity
Rotem Sorek & Pascale Cossart
doi:10.1038/nrg2695
December 2009 Volume 10 No 12
The complex eukaryotic transcriptome: unexpected pervasive transcription and novel small RNAs
Alain Jacquier
doi:10.1038/nrg2683
October 2009 Volume 10 No 10
ChIP–seq: advantages and challenges of a maturing technology
Peter J. Park
doi:10.1038/nrg2641
September 2009 Volume 10 No 9
Insights from genomic profiling of transcription factors
Peggy J. Farnham
doi:10.1038/nrg2636
January 2009 Volume 10 No 1
RNA–Seq: a revolutionary tool for transcriptomics
Zhong Wang, Mark Gerstein & Michael Snyder
doi:10.1038/nrg2484
