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Non-invasive techniques for prenatal diagnosis are extremely advantageous in terms of both safety and cost. The discovery of fetal nucleic acids in the maternal plasma has led to the development of many non-invasive tests.
Transformation-associated recombination (TAR) cloning usesin vivorecombination in yeast to isolate large chromosomal segments from complex genomes. Although the principles of TAR cloning date back to the 1990s, recent modifications have opened up promising new applications of this technology.
