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Two studies published in the journal Developmental Cell suggest that changes to the RNA payload of sperm that occur during maturation in the epididymis help ensure successful embryo development in mice.
Two studies use targeted sequencing to identify features of clonal haematopoiesis that may predict the risk of developing acute myeloid leukaemia years before diagnosis.
A paper in Nature Genetics reports a high-quality reference genome for the koala, with insights into its specialized lifestyle, and potential applications in vaccine development and conservation strategies.
A study in Nature Biomedical Engineering reports improvements in neurological symptoms in a mouse model of fragile X syndrome after non-viral delivery of Cas9 ribonucleoproteins to the brain.
Many eukaryotic proteins, including key transcription regulators, contain intrinsically disordered regions (IDRs), which serve as flexible interaction platforms. The molecular understanding of IDR-based interactions is now emerging, providing new insights into how IDRs promote protein compartmentalization and/or phase separation and how these processes regulate gene expression.
One in four UK adults over the age of 65 suffers from loneliness. An analysis of UK Biobank data has identified 15 genomic loci associated with loneliness and reports a possible causal link between obesity and loneliness and depression.
Two independent studies now show that polymerization of branched actin at DNA double-strand breaks (DSBs) mediates chromatin dynamics associated with homology-directed repair and is required for a robust and error-free DSB repair process.
Unlike most organisms, planaria maintain pluripotent stem cells (PSCs) beyond embryogenesis. A new study reports the prospective identification and isolation of a neoblast subpopulation containing adult PSCs, characterization of which should help uncover the mechanisms underlying pluripotency and tissue regeneration.
A publication in Science reports the sequencing, assembly and comparative analysis of new and improved great ape genomes and provides a stepping stone for the identification of genetic variation specific to humans.
A study in Genome Research reports the impact of genetic variation near splice sites on human disease and may help prioritize and functionally interpret newly identified variants.
A new study reveals that DNA methylation-mediated repression of gene expression regulates early eye development in blind cave morphs of Astyanax mexicanus.
A paper in Cell presents split–pool recognition of interactions by tag extension (SPRITE), a method that enables the identification of multiple, simultaneously occurring DNA and RNA interactions genome-wide within the nucleus.
A recent study in Science reports the mechanism by which temperature affects sex determination in the red-eared slider turtle, Trachemys scripta elegans.
Three new studies in Nature and Nature Biotechnology report methods for dissecting transcriptomic cell phenotypes and lineage history simultaneously by combining single-cell RNA sequencing (scRNA-seq) with CRISPR-based lineage tracing.
A new study in Cell reports genomic selection of physiological adaptations to hypoxia in breath-hold diving marine hunter–gatherers, the indigenous Bajau people of Southeast Asia.
A recent analysis in Nature Genetics combines genome-wide association study summary statistics with gene expression data to identify the contribution of different cell types and tissues to disease.
A paper in Science reports a strategy that combines rapid chemical-genetic perturbation with measurements of immediate gene expression changes to identify targets of transcriptional regulators.
