Review
Nature Reviews Genetics 9, 583-593 (August 2008) | doi:10.1038/nrg2398
Tuning gene expression to changing environments: from rapid responses to evolutionary adaptation
There is an Erratum (January 2009) associated with this article.
Luis López-Maury1, Samuel Marguerat1 & Jürg Bähler1 About the authors
Abstract
Organisms are constantly exposed to a wide range of environmental changes, including both short-term changes during their lifetime and longer-term changes across generations. Stress-related gene expression programmes, characterized by distinct transcriptional mechanisms and high levels of noise in their expression patterns, need to be balanced with growth-related gene expression programmes. A range of recent studies give fascinating insight into cellular strategies for keeping gene expression in tune with physiological needs dictated by the environment, promoting adaptation to both short- and long-term environmental changes. Not only do organisms show great resilience to external challenges, but emerging data suggest that they also exploit these challenges to fuel phenotypic variation and evolutionary innovation.
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Author affiliations
- Department of Genetics, Evolution and Environment, and UCL Cancer Institute, University College London, London WC1E 6BT, UK.
Correspondence to: Jürg Bähler1 Email: jurg@sanger.ac.uk
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