Complex traits: A wider view of networks | PDF (197 KB)

p321 | doi:10.1038/nrg2367

Human disease: A two-pronged model of polyglutamine disease | PDF (177 KB)

p322 | doi:10.1038/nrg2366

Gene regulation: Repositioning tunes expression | PDF (139 KB)

p322 | doi:10.1038/nrg2377

Evolution: Scrutinizing mammalian reproductive inventions | PDF (117 KB)

p324 | doi:10.1038/nrg2375

Human disease: Rare but rich pickings | PDF (246 KB)

p326 | doi:10.1038/nrg2370

Epigenetics: Pioneering the path from methylation to transcription | PDF (138 KB)

p326 | doi:10.1038/nrg2378

Genetic programming of liver and pancreas progenitors: lessons for stem-cell differentiation

Kenneth S. Zaret

p329 | doi:10.1038/nrg2318

Newly specified hepatic and pancreatic progenitors, which originate from common endodermal domains, are able to reverse their course and develop into gut progenitors. Understanding what underlies such programming reversal and intrinsic regenerative capacities should illuminate the basis of cellular plasticity and facilitate targeted programming of stem cells.

• Abstract
• Full Text
• PDF (830 KB)

Advances in autism genetics: on the threshold of a new neurobiology

Brett S. Abrahams & Daniel H. Geschwind

p341 | doi:10.1038/nrg2346

The highly heterogeneous nature of autism has made this syndrome difficult to dissect genetically. Recent work has highlighted the importance of de novo and inherited copy number variation as well as common genetic risk variants in defining potential biological mechanisms of disease.

• Abstract
• Full Text
• PDF (1,007 KB)
• Supplementary information

Genome-wide association studies for complex traits: consensus, uncertainty and challenges

Mark I. McCarthy, Gonçalo R. Abecasis, Lon R. Cardon, David B. Goldstein, Julian Little, John P. A. Ioannidis & Joel N. Hirschhorn

p356 | doi:10.1038/nrg2344

Genome-wide association studies have led to an improved understanding of the genetic basis of common diseases. Following the first wave of such studies, this Review takes a critical look at progress so far and considers how future studies can be optimized.

• Abstract
• Full Text
• PDF (824 KB)

Segmental patterning of the vertebrate embryonic axis

Mary-Lee Dequéant & Olivier Pourquié

p370 | doi:10.1038/nrg2320

Established during embryogenesis, vertebrate segmentation is most conspicuous at the level of the periodic arrangement of vertebrae in the spine. Since the identification of the segmentation clock, which is a travelling oscillator, the generation of segmental pattern in the presomitic mesoderm has been a particular focus of attention.

• Abstract
• Full Text
• PDF (723 KB)

Coordination of gene expression between organellar and nuclear genomes

Jesse D. Woodson & Joanne Chory

p383 | doi:10.1038/nrg2348

Tight coordination of gene expression between the nucleus and genome-containing organelles (mitochondria and chloroplasts), and between organelles themselves, is essential to the survival of a eukaryotic cell. This article reviews our current understanding of the mechanisms behind this multidirectional signalling.

• Abstract
• Full Text
• PDF (527 KB)
• Supplementary information