Table of contents
From the editors
p245 | doi:10.1038/nrg2353
Research Highlights
Gene expression: Of ChIPs and flies | PDF (145 KB)
p247 | doi:10.1038/nrg2343
Evolution: Arabidopsis' hidden potential | PDF (138 KB)
p248 | doi:10.1038/nrg2350
Epigenetics: Across the generations | PDF (163 KB)
p248 | doi:10.1038/nrg2357
In brief
Gene expression | Chromatin | Quantitative traits | Model organisms | PDF (102 KB)
p249 | doi:10.1038/nrg2358
Human genetics: Not-so-identical twins | PDF (169 KB)
p250 | doi:10.1038/nrg2356
Epigenetics: DNA methylation gets dynamic | PDF (127 KB)
p250 | doi:10.1038/nrg2359
Stem cells: MicroRNAs promote differentiation | PDF (201 KB)
p251 | doi:10.1038/nrg2352
Population genetics: Rich pastures for cattle genomics | PDF (85 KB)
p252 | doi:10.1038/nrg2347
Human disease: Rare disease mapped from just three cases | PDF (135 KB)
p252 | doi:10.1038/nrg2351
Gene expression: Transcription at the edge | PDF (135 KB)
p253 | doi:10.1038/nrg2354
In brief
Population genetics | Genetic screens | Gene expression | Evolution | PDF (102 KB)
p253 | doi:10.1038/nrg2355
Reviews
Article series: Fundamental concepts in genetics
Heritability in the genomics era — concepts and misconceptions
Peter M. Visscher, William G. Hill & Naomi R. Wray
p255 | doi:10.1038/nrg2322
Heritability is one of the oldest parameters in genetics, but also one of the most misunderstood. The authors explore exactly what heritability means, the pitfalls to avoid when using it, and its continued relevance in the genomics era.
Rates of evolutionary change in viruses: patterns and determinants
Siobain Duffy, Laura A. Shackelton & Edward C. Holmes
p267 | doi:10.1038/nrg2323
It is conventionally thought that there is a simple relationship between viral mutation rates and polymerase fidelity. This article argues that the pattern of virus evolution is also shaped by other aspects of viral biology.
Quiet as a mouse: dissecting the molecular and genetic basis of hearing
Steve D. M. Brown, Rachel E. Hardisty-Hughes & Philomena Mburu
p277 | doi:10.1038/nrg2309
Genetic, biochemical, ultrastructural and physiological studies of mouse mutants have crucially advanced our understanding of the molecular mechanisms of hearing. A detailed picture is emerging of the protein complexes that are responsible for the growth and cohesion of the stereocilia bundle — a complex subcellular structure at the core of the auditory apparatus.
Comparing whole genomes using DNA microarrays
David Gresham, Maitreya J. Dunham & David Botstein
p291 | doi:10.1038/nrg2335
Microarray-based approaches are a fast, flexible and inexpensive alternative to genome sequencing for characterizing the genomes of many individuals within a species. This article reviews the advances that are making microarrays a viable choice for detecting all forms of genetic diversity.
Approaches to comparative sequence analysis: towards a functional view of vertebrate genomes
Elliott H. Margulies & Ewan Birney
p303 | doi:10.1038/nrg2185
Comparative genomics is a promising approach for identifying functional components of genomes. However, many challenges remain, relating to the quality and quantity of sequence data, how sequences are aligned and, ultimately, how functional elements are recognized.
Perspective
Essay
The road to genome-wide association studies
Leonid Kruglyak
p314 | doi:10.1038/nrg2316
In this Essay, Leonid Kruglyak looks back at the concepts, resources and techniques that laid the necessary foundations for the recent explosion of genome-wide association studies, focusing on the less well-chronicled days before the launch of the HapMap project and speculates about future developments.
Correspondence
Correspondence: Meiotic chromosome pairing and recombination take refuge in the telomeres
Rayasandram Muniyappa Ranganath
p318 | doi:10.1038/nrg2224-c1