Review
Nature Reviews Genetics 8, 699-710 (September 2007) | doi:10.1038/nrg2144
Integrating physical and genetic maps: from genomes to interaction networks
Andreas Beyer1,2, Sourav Bandyopadhyay1 & Trey Ideker1 About the authors
Abstract
Physical and genetic mapping data have become as important to network biology as they once were to the Human Genome Project. Integrating physical and genetic networks currently faces several challenges: increasing the coverage of each type of network; establishing methods to assemble individual interaction measurements into contiguous pathway models; and annotating these pathways with detailed functional information. A particular challenge involves reconciling the wide variety of interaction types that are currently available. For this purpose, recent studies have sought to classify genetic and physical interactions along several complementary dimensions, such as ordered versus unordered, alleviating versus aggravating, and first versus second degree.
- View At a Glance
Author affiliations
- Department of Bioengineering, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.
- BIOTEC, Technische Universität Dresden, 01062 Dresden, Germany.
Correspondence to: Trey Ideker1 Email: trey@bioeng.ucsd.edu
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
From E-MAPs to module maps: dissecting quantitative genetic interactions using physical interactionsMolecular Systems Biology Article (15 Jul 2008)
