Review
Nature Reviews Genetics 8, 619-631 (August 2007) | doi:10.1038/nrg2158
Mutation rate variation in multicellular eukaryotes: causes and consequences
Charles F. Baer1, Michael M. Miyamoto1 & Dee R. Denver2 About the authors
Abstract
A basic knowledge about mutation rates is central to our understanding of a myriad of evolutionary phenomena, including the maintenance of sex and rates of molecular evolution. Although there is substantial evidence that mutation rates vary among taxa, relatively little is known about the factors that underlie this variation at an empirical level, particularly in multicellular eukaryotes. Here we integrate several disparate lines of theoretical and empirical inquiry into a unified framework to guide future studies that are aimed at understanding why and how mutation rates evolve in multicellular species.
- View At a Glance
Author affiliations
- Department of Zoology, University of Florida, Gainesville, Florida 32611, USA.
- Department of Zoology and Center for Genome Research and Biocomputing, Oregon State University, Corvallis, Oregon 97331, USA.
Correspondence to: Charles F. Baer1 Email: cbaer@zoo.ufl.edu
Correspondence to: Dee R. Denver2 Email: denver@cgrb.oregonstate.edu
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
The muddle about mutationsNature News and Views (08 May 1997)
Evolutionary biology Fruitfly genome is not junkNature News and Views (20 Oct 2005)
See all 3 matches for News And ViewsRESEARCH
The mechanisms of acute ischemic injury in the cell processes of developing white matter astrocytesJournal of Cerebral Blood Flow & Metabolism Original Article
Toward fluorescence nanoscopyNature Biotechnology Research (01 Nov 2003)
See all 16 matches for Research
