Review
Nature Reviews Genetics 8, 104-115 (February 2007) | doi:10.1038/nrg2041
Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions
Christian Lanctôt1, Thierry Cheutin2, Marion Cremer1, Giacomo Cavalli2 & Thomas Cremer1 About the authors
Abstract
The regulation of gene expression is mediated by interactions between chromatin and protein complexes. The importance of where and when these interactions take place in the nucleus is currently a subject of intense investigation. Increasing evidence indicates that gene activation or silencing is often associated with repositioning of the locus relative to nuclear compartments and other genomic loci. At the same time, however, structural constraints impose limits on chromatin mobility. Understanding how the dynamic nature of the positioning of genetic material in the nuclear space and the higher-order architecture of the nucleus are integrated is therefore essential to our overall understanding of gene regulation.
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Author affiliations
- Department Biologie II, Ludwig-Maximilians Universität, Grosshadernerstr. 2, Planegg-Martinsried, Germany.
- Institute of Human Genetics, CNRS, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
Correspondence to: Christian Lanctôt1 Email: christian.lanctot@lrz.uni-muenchen.de
Correspondence to: Thomas Cremer1 Email: thomas.cremer@lrz.uni-muenchen.de
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