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Understanding the complex genetic basis of coronary artery disease — now the world's biggest killer — will provide a vital boost towards developing new prognostic and therapeutic strategies. Recent progress towards this goal has been made by using large-scale, systematic, genome-wide approaches.
Crop genomes contain important information about mechanisms of domestication and the origins of the immense diversity of the angiosperms. This Review evaluates several approaches that can be taken to unlock this information, from full-genome sequencing to comparative genomics.
Global population growth and the increasing number of infertile couples are opposing health issues that can be addressed by investigating the molecular-genetic basis of mammalian preimplantation and implantation biology, thereby leading to novel contraceptives and more effective reproductive technologies.
Microarray technology has led the way towards global and parallel analysis of cellular processes. The use of microarrays in transcription profiling and genotyping is now well established and the technology is being adapted to a wide range of applications, including genome-wide epigenetic analysis and on-chip synthesis.
Spliceosomal introns are thought to have had a central role in shaping modern genomes. Recent studies have shed new light on the timing of intron evolution, mechanisms of intron loss and gain, and the forces that have driven these processes.
With genetics and genomics moving at such a fast pace it is difficult to know where to find accurate and up-to-date information. This is a guide to online resources about genetics, which are aimed at teachers, students, health professionals and the general public.
Traditional QTL mapping approaches inadequately capture the complexity of gene networks. The authors show how functional mapping — a general statistical mapping framework — can provide a useful quantitative and testable framework for assessing the interplay between gene actions or interactions during development.
