Table of contents
March 2006 Vol 7 No 3
Research Highlights
Functional genomics: Affinity for enhancer prediction | PDF (88 KB)
p156 | doi:10.1038/nrg1812
Evolutionary genetics: It doesn't have to be...perfect | PDF (85 KB)
p157 | doi:10.1038/nrg1814
Plant development: How does your garden grow? | PDF (58 KB)
p157 | doi:10.1038/nrg1824
Cancer genomics: Complete coverage? | PDF (101 KB)
p158 | doi:10.1038/nrg1813
Therapeutics: Into the groove | PDF (98 KB)
p158 | doi:10.1038/nrg1816
In brief
Gene expression | Complex traits | Gene expression | Evolution | PDF (65 KB)
p158 | doi:10.1038/nrg1820
In brief
Ageing | Technology | Evolution | PDF (61 KB)
p159 | doi:10.1038/nrg1821
In the news
The solution to a sticky problem | PDF (47 KB)
p160 | doi:10.1038/nrg1815
Human disease: Why crawl when you can leap? | PDF (113 KB)
p160 | doi:10.1038/nrg1818
Molecular evolution: Missing links in protein evolution | PDF (103 KB)
p160 | doi:10.1038/nrg1819
Epigenetics: The open secret of pluripotentiality | PDF (93 KB)
p161 | doi:10.1038/nrg1823
Ethics watch
Desperate times call for desperate measures | PDF (68 KB)
p162 | doi:10.1038/nrg1810
Chromosome biology: Slicing up the centromere | PDF (74 KB)
p162 | doi:10.1038/nrg1817
Reviews
Genetic susceptibility to coronary artery disease: from promise to progress
Hugh Watkins & Martin Farrall
p163 | doi:10.1038/nrg1805
Understanding the complex genetic basis of coronary artery disease — now the world's biggest killer — will provide a vital boost towards developing new prognostic and therapeutic strategies. Recent progress towards this goal has been made by using large-scale, systematic, genome-wide approaches.
Leafing through the genomes of our major crop plants: strategies for capturing unique information
Andrew H. Paterson
p174 | doi:10.1038/nrg1806
Crop genomes contain important information about mechanisms of domestication and the origins of the immense diversity of the angiosperms. This Review evaluates several approaches that can be taken to unlock this information, from full-genome sequencing to comparative genomics.
Roadmap to embryo implantation: clues from mouse models
Haibin Wang & Sudhansu K. Dey
p185 | doi:10.1038/nrg1808
Global population growth and the increasing number of infertile couples are opposing health issues that can be addressed by investigating the molecular-genetic basis of mammalian preimplantation and implantation biology, thereby leading to novel contraceptives and more effective reproductive technologies.
Microarray technology: beyond transcript profiling and genotype analysis
Jörg D. Hoheisel
p200 | doi:10.1038/nrg1809
Microarray technology has led the way towards global and parallel analysis of cellular processes. The use of microarrays in transcription profiling and genotyping is now well established and the technology is being adapted to a wide range of applications, including genome-wide epigenetic analysis and on-chip synthesis.
The evolution of spliceosomal introns: patterns, puzzles and progress
Scott William Roy & Walter Gilbert
p211 | doi:10.1038/nrg1807
Spliceosomal introns are thought to have had a central role in shaping modern genomes. Recent studies have shed new light on the timing of intron evolution, mechanisms of intron loss and gain, and the forces that have driven these processes.
Perspectives
Science and society
Teaching resources for genetics
Susanne B. Haga
p223 | doi:10.1038/nrg1803
With genetics and genomics moving at such a fast pace it is difficult to know where to find accurate and up-to-date information. This is a guide to online resources about genetics, which are aimed at teachers, students, health professionals and the general public.
Opinion
Functional mapping — how to map and study the genetic architecture of dynamic complex traits
Rongling Wu & Min Lin
p229 | doi:10.1038/nrg1804
Traditional QTL mapping approaches inadequately capture the complexity of gene networks. The authors show how functional mapping — a general statistical mapping framework — can provide a useful quantitative and testable framework for assessing the interplay between gene actions or interactions during development.