Abstract

Although the assumption of the neutral theory of molecular evolution — that some classes of mutation have too small an effect on fitness to be affected by natural selection — seems intuitively reasonable, over the past few decades the theory has been in retreat. At least in species with large populations, even synonymous mutations in exons are not neutral. By contrast, in mammals, neutrality of these mutations is still commonly assumed. However, new evidence indicates that even some synonymous mutations are subject to constraint, often because they affect splicing and/or mRNA stability. This has implications for understanding disease, optimizing transgene design, detecting positive selection and estimating the mutation rate.

Author affiliations

1. Center for Integrative Genomics, University of Lausanne, Génopode building, CH-1015 Lausanne, Switzerland.
2. Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK.

Correspondence to: J. V. Chamary¹ Email: j.v.chamary@unil.ch

Correspondence to: Laurence D. Hurst² Email: l.d.hurst@bath.ac.uk

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