Review
Nature Reviews Genetics 7, 862-872 (November 2006) | doi:10.1038/nrg1964
Genetics of global gene expression
Matthew V. Rockman1 & Leonid Kruglyak1 About the authors
Abstract
A new field of genetic analysis of global gene expression has emerged in recent years, driven by the realization that traditional techniques of linkage and association analysis can be applied to thousands of transcript levels measured by microarrays. Genetic dissection of transcript abundance has shed light on the architecture of quantitative traits, provided a new approach for connecting DNA sequence variation with phenotypic variation, and improved our understanding of transcriptional regulation and regulatory variation.
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Author affiliations
- Lewis-Sigler Institute for Integrative Genomics and Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544, USA.
Correspondence to: Leonid Kruglyak1 Email: leonid@genomics.princeton.edu
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