Abstract

Obesity is an important cause of morbidity and mortality in developed countries, and is also becoming increasingly prevalent in the developing world. Although environmental factors are important, there is considerable evidence that genes also have a significant role in its pathogenesis. The identification of genes that are involved in monogenic, syndromic and polygenic obesity has greatly increased our knowledge of the mechanisms that underlie this condition. In the future, dissection of the complex genetic architecture of obesity will provide new avenues for treatment and prevention, and will increase our understanding of the regulation of energy balance in humans.

Author affiliations

1. Section of Genomic Medicine, Faculty of Medicine, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.
2. Centre National de la Recherche Scientifique, 8090 Institute of Biology, Pasteur Institute, Lille, France.

Correspondence to: Philippe Froguel^1,2 Email: p.froguel@imperial.ac.uk

Published online 10 February 2005

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